Lorcaserin (Belviq)
Is the new obesity pill a miracle drug? As with all these drugs, it’s approved by the FDA for people who are obese—they have a body mass index (BMI) greater than 30 (for example, someone who is 5’6″ would have to weigh more than 185 pounds); or for people who have a BMI greater than 27 (such as a 5’6″ person who weighs 167 or more) with an obesity-related condition such as diabetes, sleep apnea, high blood pressure or high cholesterol. You can calculate your BMI here.
Lorcaserin (Belviq) is a brand-new molecule that stimulates the area of the brain that regulates appetite and satiety, explains Scott Kahan, MD, MPH, the director of the National Center for Weight and Wellness in Washington, DC. Belviq takes aim at the brain receptors for serotonin, a brain chemical that plays a role satiety. (Serotonin also plays a role in mood regulation.)
What can you expect? Studies comprising nearly 8,000 obese and overweight people who took Belviq show an average weight loss of 3 to 3.7 percent, and those who combined the drug with diet and exercise lost even more. His rule of thumb is that if you do not lose 5 percent of your weight after 12 weeks of treatment, you likely will not respond. “We are seeing good weight loss in about 50 percent of patients and it is very safe,” he says. Both cholesterol and blood sugar levels also seem to decrease among Belviq users. Side effects may include headache, dizziness, fatigue, nausea, dry mouth, constipation, and low blood sugar for people who take drugs to treat diabetes, but there is a very low likelihood of these, he says. It is among the best weight loss pills when it comes to safety. “One of the feathers in Belviq’s hat is that it is very well tolerated,” he says. That said, people with a history of heart disease, psychiatric disorders and those who are pregnant should not take this medication. The FDA’s advisory panel initially rejected this weight loss pill due to risk of tumors seen in animal studies, and the European Medicines Agency was so concerned about the drug’s safety that it rejected Belviq. However, an analysis in JAMA indicates that Belviq is linked to fewer adverse events than other Rx weight loss pills. Try these 50 ways to lose weight without a lick of exercise.
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